Category: Anti-Depressants

Depression Treatment & Myths about Depression

Depression is a disease, so it should be treated by a doctor. And it is not recommended to postpone depression treatment – depression can last for months and years, which certainly leads to dangerous conditions. Depression therapy is carried out in two directions: Taking Canadian Pharmacy antidepressants. There is no way you should take antidepressants without consulting a doctor. Depression can be treated by various means – the choice of the attending physician will depend on several factors; Psychotherapy for depression. Treatment of depression with even the most effective medicines will be inadequate without it. The goal of this therapy is …

Depression: Symptoms, Causes & Treatment

Depression is a disease that disrupts emotional balance of a person for a long time and worsens the quality of his life (working activity, personal relationship, leisure, etc.). Depression can arise as a response to a psychological trauma or a negative event, however, this disease often develops for no apparent reason. Fortunately, depression can be cured. Talking about your problems is the first step towards recovery from depression. See in the article: Depression symptoms; Forms of depression Men’s depression; Women’s depression; Treatment of depression. Depression symptoms Sadness, anxiety or irritability; Sleeping problems, too early awakening; Loss of interest in work, …

Two Drugs Approved for Social Phobia

Two drugs that are commonly used to treat depression and generalized anxiety, venlafaxine HCl ( Tablet Effexor ® XR, Wyeth) and sertraline HCl ( Drug Zoloft ®, Pfizer), have now been approved by the Food and Drug Administration (FDA) for the treatment of Social Anxiety Disorder, sometimes called “social phobia.” Social Anxiety Disorder affects 13% of Americans and is marked by overwhelming and disabling fear of scrutiny, embarrassment, or humiliation in social situations, which the person often avoids or endures with dread. It is the third most common psychiatric disorder in the U.S. Adults with this mood disorder usually recognize that their fear is excessive. Patients …

Risk of Heart Problems With Antipsychotic Drugs

Thioridazine, an antipsychotic agent, sometimes prolongs the QT interval, but does it pose any more of a cardiac risk than haloperidol does? Researchers from the University of Pennsylvania School of Medicine say probably not, unless the dose is high. The QT interval, a measurement of the time it takes for the heart muscle to contract and relax, typically lasts for four-tenths of a second. If this duration is lengthened as a result of drug therapy, for instance, then an arrhythmia, or an interruption of the heartbeat, may occur.

Studying data from 105,718 patients from three Medicaid programs, the researchers identified patients who had more than one prescription for oral thioridazine, haloperidol (Haldol generic, Ortho-McNeil), risperidone generic (Risperidal medication, Janssen), or drug clozapine (Clozaril drug, Novartis) as well as at least two instances of a schizophrenia diagnosis. Patients with schizophrenia were compared with two control groups: patients with glaucoma and patients with psoriasis. These diseases were selected for study because periodic drug prescriptions are required for their treatment and the conditions are not thought to be associated with cardiovascular outcomes.

Compared with the glaucoma and psoriasis patients, patients taking antipsy-chotic drugs had rate ratios for cardiac arrest and ventricular arrhythmias ranging from 1.7 to 3.2 and for death ranging from 2.6 to 5.8. Compared with haloperidol drug, thioridazine did not carry higher rates for cardiac arrest, ventricular arrhythmia, or death, even in high-risk patients, women, and patients over 65. At high doses, however, thioridizane might pose a higher risk and there might be a dose-response relationship. As a result, the researchers recommend prescribing the lowest possible dose of thiori-dazine.

Doxepin Relieves Chronic Itching from Burns


Many patients whose burns have healed find that they must still contend with sometimes disabling itching, which can last for months. Because the main mechanism is thought to include increased histamine release from the wound, leading to chronic inflammation, current treatment focuses on oral antihistamines, moisturizers, and sedatives. Researchers from Brigham and Women’s Hospital in Boston, however, believe that doxepin (Generic Sinequan, Pfizer), a tricyclic compound with potent antihistamine properties, is a better choice.

In a three-month study of 31 outpatients four to 12 months after they had received burns, the patients were randomly assigned to receive standard care (an oral antihistamine with dose adjustments to improve efficacy) or doxepin cream. All patients continued to use moisturizers because doxepin cream is not a good moisturizer, the researchers say. The patients applied the doxepin cream four times a day, followed 20 minutes later by a moisturizer.

The doxepin tablet cream was effective in controlling post-burn itching, and erythema was significantly diminished. Itching disappeared in 75% of those taking doxepin but in only 20% of those taking oral antihistamines. The researchers suggest that doxepin might somehow alter the wound, perhaps by reducing the number of mast cells.

Long-Acting Venlafaxine Superior for Depression

Prescribing extended-release venlafax-ine rather than generic fluoxetine for depression might be more beneficial to patients in the long term. Researchers from Prescriptions Solutions in Costa Mesa, California, and Wyeth Research in St. Davids, Pennsylvania, found that patients taking ven-lafaxine XR were at least three times more likely to be treated adequately through the crucial first eight months.

The researchers evaluated pharmacy refill claims, which reflect the patients’ actual behavior in filling prescriptions, not necessarily the physicians’ actual treatment regimen.

Antidepressants and the Need for Blood Transfusions

Patients who take serotonergic anti-depressants might be at higher risk for bleeding during orthopedic surgery, say researchers at St. Elisabeth Hospital in Tilburg, the Netherlands. The number of blood transfusions almost quadrupled for those patients, compared with patients who were not taking antidepressants.

Of 520 patients, 26 (5%) used seroto-nergic antidepressants before surgery. Of those, six (23%) received perioperative blood transfusions. Antidepressant use was significantly associated with increased blood loss during surgery (1,109 ml for users, 582 ml for nonusers).

Serotonergic antidepressants had already been associated with bleeding disorders, and reports have raised concerns about the safety of these drugs for older patients. The researchers cite earlier studies that found possible links to bleeding-related problems. One, for instance, found a threefold increase in the risk of gastrointestinal (GI) bleeding in primary care patients; another estimated an absolute risk of eight new sero-tonergic-antidepressant-induced GI hemorrhages per 1,000 persons per year in elderly patients.
esomeprazole tablets

The researchers explain that the main mechanism for the increased risk might occur via reduced intraplatelet serotonin concentrations, which then affect platelet aggregation.

Lower platelet serotonin levels and a concurrent rise in plasma serotonin levels have also been associated with surgical procedures. Thus, patients experiencing stress from surgery may be at higher risk for bleeding complications because of platelet impairment. The combination of those two effects may act synergistically and negatively on hemo-stasis.

Recombinant human erythropoietin has the potential to reduce the need for allogeneic blood transfusions, the researchers suggest, thus avoiding or minimizing transfusion-related complications.