Nexium Application:

Gastroesophageal Reflux Disease, GERD, Erosive Esophagitis, Gastric Ulcers, Duodenal Ulcer, Zollinger-Ellison Syndrome

Nexium Generic names:

Esomeprazole, Lucen, Esopral, Axagon, Sompraz, Zoleri, Nexiam

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Nexium (Esomeprazole) decreases the amount of acid produced in the stomach.


Nexium is indicated for short-term treatment of active duodenal ulcer, active benign gastric ulcer, erosive esophagitis, heartburn and other symptoms associated with GERD (gastroesophageal reflux disease).

Dosage and Administration

Duodenal Ulcer
The recommended adult oral dose of Nexium is 20 mg once daily. Most patients heal within 4 weeks. Some patients may require an additional 4 weeks of therapy.

Gastric Ulcer
The recommended adult oral dose is 40 mg once a day for 4-8 weeks

Gastroesophageal Reflux Disease (GERD)

The recommended adult oral dose is 20 mg once a day for up to 4 weeks.

Nexium delayed release capsules should be taken before eating. Swallow the capsule whole. Do not crush, break, or chew the capsule. If you cannot swallow the capsule whole, you may open it and sprinkle the granules contained in the capsule on one tablespoonful of applesauce or yogurt and swallow it immediately; or you may mix the granules in some tap water or fruit juice and drink it immediately. The applesauce should not be hot, and the juices you may use include apple or orange juice. Do not chew or crush the granules.

Missed Dose

If you miss a dose, take this medicine as soon as possible. Then go back to your regular dosing schedule. Do not double doses.


  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
  • Keep out of the reach of children.
  • Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Warning and Precautions

Do not use Nexium if:

  • you are allergic to esomeprazole or any other benzimidazole medication such as albendazole(Albenza), or mebendazole (Vermox)
  • you are taking an HIV protease inhibitor (e.g., atazanavir).
  • Symptomic response to therapy with nexium dies not preclude the presence of gastric malignancy.
  • Pregnancy category C It is not known whether nexium is excreted in human milk.
  • Breastfeeding. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding.

Nexium should be taken before eating. Patients should be cautioned that the nexium delayed- release capsules should not be opened, chewed or crushed, and should be swallowed whole.

Drug Interactions

Nexium can prolong the elimination of diazepam, warfarin and phenytoin, drugs that are metabolized by oxidation in the liver. Although there have been clinical reports of interaction with iron salts, disulfiram, cyclosporine.


Nexium delayed-release capsules are contraindicated in patients with known hypersensitivity to any component of the formulation.

Adverse Reactions

Along with desirable effects, a medicine may cause some unwanted effects

  • Fever, pain, fatigue, malaise.
  • Chest pain
  • Angina
  • Tachycardia, bradycardia
  • Elevated blood pressure
  • Pancreatitis
  • Anorexia
  • Irritable colon
  • Fecal discoloration
  • Overt liver disease
  • Hyponatremia, hypoglycemia
  • Muscle cramps, myalgia
  • Depression, aggression

Other side effects not listed may occur in some patients. If you notice these effects, call your doctor immediately.

Drug Abuse And Dependence

There is no information to indicate that abuse or dependency occurs with NEXIUM.