The FDA has approved generic metformin HCl extended-release tablets (Glucophage® XR, Bristol-Myers Squibb) in a new dosage strength of 750 mg for the treatment of type-2 diabetes. The 750-mg tablet was developed to provide physicians with an additional option to make titration to higher doses more convenient when necessary. Glucophage® XR is already available as [...]
“Pre-diabetes”—a condition that raises a person’s risk for the development of type-2 (non-insulin-dependent) diabetes, heart disease, and stroke—is far more common in the U.S. than previously believed. Approximately 40% of American adults aged 40 to 74 (41 million people) have above-normal blood glucose levels. Pre-diabetes often evolves into type-2 diabetes within 10 years. The new [...]
Researchers have known for a while that diabetic patients are at greater risk for Alzheimer’s disease (AD) and other forms of dementia than those without diabetes, but the exact cause of this link has not been known. A study published in February 2004 suggested that insulin resistance in brain cells might affect their function, causing [...]
Novo Nordisk has announced the FDA’s approval of Levemir®, a soluble, long-acting (basal) human insulin analogue for the treatment of diabetes. This agent has already been approved for use in 37 countries. This analogue has a relatively flat action profile with a prolonged duration of action of up to 24 hours. It is indicated for [...]
The U.S. Food and Drug Administration (FDA) has approved ertapenem (Invanz®, Merck), a once-daily injectable antibiotic, for the treatment of moderate-to-severe complicated foot infections caused by pathogens in diabetic patients without osteomyelitis. This medication was approved in 2001 for adults with moderate-to-severe infections caused by common gram-positive and gram-negative aerobic and anaerobic bacteria. buy altace [...]
Not all beta blockers have the same effect on cardiovascular risk factors in patients with diabetes. The Glycemic Effects in Diabetes Mellitus Carvedilol-Metoprolol Comparison in Hypertensives (GEMINI) trial found that, in the presence of an angiotensin-converting enzyme (ACE) inhibitor or an angio-tensin-receptor blocker (ARB), the beta blocker carvedilol (e.g., Coreg medication, Glaxo-SmithKline) preserved glycemic control, [...]
There has been a debate over Avandia (Rosiglitazone), which is used in treating diabetes. It is made by GlaxoSmithKline (GSK) and earned 1.4 billion US dollars in sales last year. The aim of a drug trial was to reveal if Avandia medication raises the risk of heart attack and death from cardiovascular problems in patients [...]
