Aspirin with Ibuprofen: Safe After Heart Attack
Concerns about the safety of discharging patients with both aspirin and ibuprofen after a myocardial infarction (MI) might be unfounded, according to researchers from Yale University and Denver Health Medical Center. A retrospective study of 70,316 patients found that patients who took both drugs had a risk of death that was comparable to that of patients taking aspirin alone.
Of the 66,739 patients who were prescribed aspirin alone, 11,546 (17.5%) died. Of the 844 who were taking aspirin and ibuprofen, 118 (14%) died, as did 432 (15.8%) of the 2,733 patients who were taking aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs).
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Earlier reports that post-MI patients taking aspirin and ibuprofen were at increased risk resulted in recommendations against prescribing the two drugs together. However, the study had included only 187 patients receiving the two drugs and was not adjusted to determine the severity of cardiovascular disease. In contrast, the current retrospective study included four times as many patients, with adjustments made to measure the severity of shock, ejection fraction, and heart failure.
