More SSRIs, More Bleeding Risk
As the number of prescriptions for SSRIs has increased, so have once-rare bleeding risks—a rise in risk that has been exacerbated by the greater concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) and long-term antiplatelet regimens, among other factors.
A physician at Johns Hopkins Hospital has noted an increased frequency of bleeding complications and cautions about the possibility of SSRI-induced hemorrhages. All SSRIs exhibited anti-platelet properties, he emphasizes, and all have been implicated in bleeding episodes. Patients with even mild hereditary platelet defects are particularly at risk, as are those who are using anti-platelet drugs.
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Most of the reports cited indicate a superficial site of bleeding events. More severe internal bleeding, including life-threatening cerebral hemorrhages, was rarer. Although most bleeding events were reported in adults, children have had such complications as well. Moreover [in addition to the risks discussed on this page], using SSRIs during pregnancy may also result in hematomas and other complications in newborns.
