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Serotonin-4 Receptor Agonist for IBS with Constipation

People with irritable bowel syndrome (IBS) have a lower gastrointestinal (GI) tract that might be more sensitive and work more slowly than it should, causing abdominal pain and discomfort, bloating, and altered bowel function (constipation and/or diarrhea). Drug Tegasrod maleate (Zelnorm generic, Novartis) activates serotonin-4 receptors, which stimulates peristaltic reflex and normalizes the impaired motility [...]

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Anastrozole-Heir to Tamoxifen

Anastrozole could be the most significant treatment for breast cancer since the introduction of generic tamoxifen in the 1970s, according to initial findings from the Arimidex, Tamoxifen, Alone or in Combination (ATAC) trial of anastrozole for early breast cancer. The efficacy and safety of anastrozole (Arimidex, AstraZeneca) was compared to tamoxifen, the standard treatment for [...]

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Tamoxifen and Depression: A Long-Term Side Effect

Even if women have been taking tamoxifen citrate (Nolvadex tablet, AstraZeneca) for months, they should be observed for symptoms of depression, according to researchers who presented their findings at the American Psychiatric Association’s annual meeting in May 2003. Tamoxifen medication interferes with estrogen activity and is often prescribed for women with advanced and early breast [...]

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Generic Version of Oral Contraceptive Available

Norethindrone acetate and ethinyl estradiol tablets (Microgestin®, Watson), a generic version of the oral contraceptive Loestrin® (Pfizer), will be available in strengths of 1 mg/20 mcg, and 1.5 mg/30 mcg.

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Letrozole:A Promising Option for Endometriosis

Letrozole (Femara drug, Novartis Oncology), an aromatase inhibitor that is used to prevent breast cancer recurrence in postmenopausal women, shows promise in the treatment of endometriosis. Endometriosis, which affects 10% to 15% of women of childbearing age, results when tissue that is similar to the uterine lining grows elsewhere in the body. It causes chronic [...]

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Alendronate for Bone Disease in Cystic Fibrosis

Thanks to some treatment advances, patients with cystic fibrosis (CF) are living much longer; however, with longer lives have come more health problems. Bone disease, for instance, is now a major concern for these patients; it can lead to pathological fractures and kyphosis and might even prevent them from being considered suitable candidates for lung [...]

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Olanzapine/Fluoxetine Combination for Bipolar Depression

The U.S. Food and Drug Administration (FDA) has approved Symbyax™ (Eli Lilly) for the treatment of depressive episodes associated with bipolar disorder. Symbyax™, a combination of olanzapine, the active ingredient in Generic Zyprexa, and fluoxetine tablet, the active ingredient in Prozac®, is the first FDA-approved medication for bipolar depression, a notoriously difficult-to-treat condition that afflicts [...]

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