NEXIUM Drug Is Effective In Upper GI Symptoms While Using NSAIDS
James M. Scheiman, M.D., Division of Gastroenterology, Department of Internal Medicine, University of Michigan, and Ann Arbor, Michigan suppose that people who use non-steroidal anti-inflammatory drugs (NSAIDs) regularly undergo upper GI disturbances including dyspepsia, abdominal pain, and heartburn.
In spite of lowering or discontinuing the NSAID therapy might ease GI symptoms, these choices often don’t solve the problem for patients with chronic diseases.
The American Journal of Gastroenterology published the data from two clinical trials, connected with examination of Generic Nexium (esomeprazole magnesium) in reducing upper gastrointestinal (GI) symptoms.
The study involved 595 and 554 patients, respectively, who were continuous NSAID users. In the trials, patients received NEXIUM drug or placebo. The specialists estimated the average change in pain based on a seven-point patient-assessed scale (0 = no pain to 6 = very severe pain). The trials revealed that Esomeprazole 20 mg and Esomeprazole 40 mg improved symptoms in the second day of treatment and provided significantly faster symptom relief, compared with placebo. In one trial, 7 consecutive days of symptom relief occurred within an average of 11 and 10 days for patients taking Nexium tablets, respectively, against 17 days for placebo. In the other trial, 7 consecutive days of symptom relief occurred within an average of 10 and 11 days for patients cured with Esomeprazole drug, respectively, versus 21 days for placebo.
The safety profile of NEXIUM medication among continuous NSAID users was similar to placebo in both trials.
Therefore, these two trials demonstrated that Nexium (Esomeprazole) can be approved as an effective medication in reducing upper GI symptoms of patients on chronic NSAID therapy.
